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What Are the Common Side Effects of Zoloft®?

Side effects of Zoloft® may differ with the patient's age. Some of the most common side effects include of Zoloft® include:

  • Nausea (in up to 30% of people)
  • Insomnia (up to 19%)
  • Diarrhea (up to 24%)
  • Dizziness (up to 17%)
  • Dry mouth (up to 16%)
  • Fatigue and drowsiness (up to 16% and 15%)
  • Indigestion (up to 13%)
  • Shakiness or tremor (up to 11%)
  • Loss of appetite (up to 11%)

Some patients have also reported sexual side effects. General sexual side effects include decreased sex drive (up to 11%), ejaculation failure, and impotence. These varied among the type of patient disorder the drug was prescribed for. Decreased sex drive was most common in patients taking Zoloft® for obsessive-compulsive disorder or premenstrual dysphoric disorder. Failure to ejaculate happened most often in men taking the drug for panic disorder.

Other Common Side Effects

  • Increased sweating
  • Feelings of burning or tingling
  • Pain
  • Headache
  • Weight loss
  • Stomach pain
  • Constipation
  • Vision changes
  • Hot flashes
  • Nervousness

Zoloft Side Effects for Children

In children, side effects are similar to those in adults except some seem to occur more often. These include:

  • Fever
  • Hyperactivity
  • Urinary incontinence
  • Aggressiveness
  • Sinus infection
  • Bloody nose
  • Red or purple discolorations on the skin

Serious side effects in children as well as adults also may occur. Some, such as serotonin syndrome or increased severity of depression, can be life-threatening.